The Biacore S200 SPR instrument can measure interactions of various sample types, from low molecular weight drug candidates to high molecular weight proteins (also DNA, RNA, polysaccharides, lipids, cells, and viruses) in various sample environments (e.g., DMSO-containing buffers, plasma, and serum)

The Biochemical Assay Core provides a consolidated, highly specialized, well equipped and professionally staffed analytical laboratory capable of performing a wide variety of immunoassays, clinical chemistry and biochemical analyses.

The Biochemistry Mass Spectrometry shared equipment houses a Thermo LTQ Mass Spectrometer for walk-up use for peptide and protein analysis.

Preclinical research services.

The facility provides service for routine 1D and 2D NMR methods, and can also provide consultation and collaborative assistance with the acquisition and analysis of multidimensional, multinuclear protein NMR spectra.

Services cover the spectrum of cancer-related and non-cancer research including: experimental design, sample size calculation, randomization, data analysis, design and analysis of clinical trials, observational studies and surveys, assistance with public databases and innovative methods development.

BSB Bulk gas billing

houses a variety of state-of-the-art microscopic imaging systems including several confocal microscopes, a laser microdissection system and whole slide scanners. Core users will be trained and consulted on the instrumentation, software, and analysis.

Advanced equipment for single cell (Chromium Controller, Chromium X) sequencing preparation and spatial genomics (Visium CytAssist) for self-use.

ATRU is designed to provide an optimal clinical research environment for both research participants and translational investigators.

The CVRC Confocal Core offers training and use of a range of Nikon microscopes including laser scanning confocal, inverted and upright widefield equipment.

The National Cancer Institute’s (NCI) National Clinical Trials Network (NCTN) designated the MCW Cancer Center as a Lead Academic Participating Site (LAPS) for the strength and innovation of its ongoing research and science and robust participation in its clinical trials.

Equipment calendars for Cancer Center users

The Cardiovascular Academic Initiative is an organized clinical and translational initiative to focus and support the cardiovascular academic missions and intertwine them with the clinical missions of MCW.

Services include human iPSC reprogramming from peripheral blood monocytes or fibroblasts (skin biopsy); human iPSC cell line differentiation into endothelial cells, cardiomyocytes, or vascular smooth muscle cells; and iPSC CRISPR gene knockout/knock-in or single nucleotide editing.

Offer 1) state-of-the-art production and processing of cell therapy products including on-site CAR-T cell manufacturing, and 2) access to cutting-edge instrumentation for immune profiling (Berkeley Lights Optofluidics, Droplet digital PCR, Isoplexis, Luminex) and immune-oncology consulting services.

Provides high-field MRI for functional MRI, structural imaging, dynamic contrast imaging, and diffusion imaging. Animal preparation including survival surgery and post-imaging support can be performed in our facility.

Provides specialized resources including gnotobiotic and axenic rodent husbandry, and state-of-the-art microbial bioinformatics including 16S rRNA gene sequencing, microbial metagenomics and RNA sequencing, and spatial microbial transcriptomics.

Technical support and training for multicolor analytical flow cytometry and cell sorting; operator-assisted cell sorting in both standard and BSL-2+ modes; consultation for application, assay development and data analysis; and advanced data interpretation.

CAP accredited laboratory that offers a full range of routine and specialized histological, immunological and related services. Training is provided by ASCP certified Histologists with analysis from an American Board of Pathology certified Pathologist.

Provides high resolution measurements of metabolic rate, core body temperature, body composition, food/water intake behaviors, caloric density, thermal imaging, bioimpedance and electrolyte flux, fecal material transfer, and blood pressure to the MCW research community.

Fujifilm VisualSonics Vevo 3100 preclinical high frequency/resolution imaging system for preclinical in vivo imaging. Transducers: MX250, MX550D, MX700 are available for image-guided injections, color doppler, contrast imaging & 4D. Isoflurane sedation, warming platforms & VevoLAB data analysis .

Ideal for performing serial evaluations of cardiac function or real-time monitoring during and after pharmacological or therapeutic intervention.

Provides access to population-based data, cancer epidemiology and database expertise, cancer burden in the catchment area, and geospatial mapping and analysis. Assists in accessing and utilizing electronic health record (EHR) data, including -omics data, and matching patients to clinical trials.

MCW Human Research Protection Program’s (HRPP) oversees and supports the MCW Institutional Review Boards (IRBs) which review all research studies involving human subjects for safety, compliance with regulations, scientific quality, and ethical standards.

Automated image acquisition allows analysis of incubated cells for days, weeks or months while they are maintained in a stationary, stable environment. Investigators can gather data and gain insights into the morphology, movement and function of cell models over an extended time period .

Liquid Nitrogen service

Supports research effort by expertly designing, fabricating, repairing, and calibrating research instrumentation tailored to lab-specific needs. Services provided in-house at a fraction of the cost of commercial vendors, the Core enables cutting-edge research while maximizing budget efficiency.

An internal resource for MCW faculty, staff, students and residents. We can accommodate requests from staff at clinical affiliates (Froedtert Hospital, Children's Wisconsin, Versiti Blood Research Institute, VA) as cash or check orders.

Offers interpreter and written translation services for clinical research projects connected to MCW, Froedtert Hospital, Children’s Wisconsin, and CTSI Partner Institutions. Informed consent, ongoing safety assessments, interviews, diet recalls, and clinical data can all be obtained by utilizing the

Provides services associated with human biospecimens including tissue and blood processing, RNA/DNA extraction, tissue analytics, and storage. Biorepositories: General Tissue and Tumor Bank, Maternal Bank, the COVID-19 Bank, and the MCW Cancer Center Immuno-oncology Bone Marrow Bank.

Provides short read (Illumina) and long read (Oxford Nanopore) sequencing (NGS), single cell sequencing and spatial genomic analysis, and NanoString nCounter applications. Analysis services include study design, data acquisition, data analysis, and publication.

Offers a variety of confocal imaging systems for specialized imaging of neuronal tissue, including the AxL Cleared Tissue Light Sheet Microscope along with appropriate software including Bitplane Imaris 10.0 F1 package and SVI Huygens Professional deconvolution software.

Enable laboratories within the Medical College of Wisconsin to perform behavioral analysis on rodents. The center is equipped with up-to-date experimental devices, analysis software, multifunctional rooms, and the ability to reserve time, space and equipment for your own research needs.

OnCore is a user-friendly and comprehensive clinical trial management system (CTMS) that supports day-to-day activities including: Study activation and life-cycle management, Regulatory management, Subject and visit tracking, Financial management, Comprehensive reporting and Electronic data capture.

Provides access to the PROVEO 8 F42 – Premium Ophthalmic surgical microscope with intraoperative Optical Coherence Tomography (OCT), used to perform precise ocular injections. Devices are available for imaging and measuring various aspects of eye anatomy and function in multiple species.

The Electron Microscopy laboratory offers tissue processing, immunoelectron microscopy, negative staining, enzyme cytochemistry, ultrastructural electron tomography and TEM training. The Light Microscopy laboratory services include training for independent use and assisted use for spinning disc conf

Room scheduling for Pharm Tox Surgical spaces

Utilizes three x-ray instruments from Precision capable of irradiating both small animals and cells. These units are currently implemented to develop therapeutics to mitigate radiation damage to radiosensitive organs such as bone marrow, heart, lungs, and kidneys.

Provides comprehensive consulting in qualitative research methodologies to MCW faculty, staff, and trainees. Our center is made up of qualitative methods experts focusing on community-engaged research, with grant preparation on funded intra- and extramural projects.

The Radiation Safety Badge Program ensures limited exposure to radioactive materials in labs and clinical settings.

, supports the assessment of tumor response to therapy guided by board certified radiologists. The QIL support clinical trials using Precision Imaging Metrics software to track and maintain clinical trial response criteria.

Maintains and supplies several rat strains as well as rat genotyping services. Offers genotyping assays to detect transgenic, knock-out, and knock-in mutations and can assist with assay and primer design.

Services include custom production of novel transgenic, gene knockout, and gene knockin rat and mouse models and management of rat breeding models. The facility can provide both sperm and embryo cryopreservation/recovery, IVF, ICSI, pronuclear microinjection of CRISPR and DNA/BAC constructs.

Protein Production: supply high quality homogeneous proteins using a variety of expression systems including baculovirus/insect cell, HEK293, CHO, and E.coli. CryoEM : houses a Thermo Glacios 200kV Cryo-TEM configured to carry out single particle analysis in support of protein structure derivations

inactive

Provides expertise and state-of-the-art instrumentation for MCW investigators and cancer center members to explore cancer and non-cancer metabolism by enabling users to run mass spectrometry analyses, bioenergetic and redox function analyses, pre-clinical imaging and therapy response.